Endocrine Abstracts

Successful surgery for pancreatic neuro-endocrine tumours (NET) requires accurate tumour localisation. Interpretation of cross-sectional imaging is often difficult, particularly after pancreatic surgery. Imaging by somatostatin-receptor-scintigraphy with indium-labelled octreotide may be useful in identifying recurrent disease; however, octreotide scans may be negative in some pancreatic NET, due to a low level of expression of somatostatin receptors. The GLP-1 receptor is abu...

Introduction: Histology is a poor predictor of the malignant potential of phaeochromocytomas and paragangliomas (PPGL) and only the presence of distant metastasis confirms malignancy. This study reviews patterns of recurrence, treatment and mortality in patients with malignant PPGL presenting to our department at UCLH over 30 years.Materials and Methods: In our series of 128 patients with PPGL, 26 (20%) with maligna...

Introduction: Histology is a poor predictor of the malignant potential of phaeochromocytomas and paragangliomas (PPGL) and only the presence of distant metastasis confirms malignancy. This study reviews patterns of recurrence, treatment and mortality in patients with malignant PPGL presenting to our department at UCLH over 30 years.Materials and Methods: In our series of 128 patients with PPGL, 26 (20%) with maligna...

Background: Characterisation of large adrenal lesion is challenging. There is no single robust imaging marker in defining benignity, especially for lesions which are greater than 4cm and are believed to carry increased risk of malignancy.A radiolabelled cholesterol analog tracer, I-131-Norcholesterol (NP-59), localises to adrenal cortical lesions. It has an established role in Conn’s syndrome. It is not expected to concent...

Background: Characterisation of large adrenal lesion is challenging. There is no single robust imaging marker in defining benignity, especially for lesions which are greater than 4cm and are believed to carry increased risk of malignancy.A radiolabelled cholesterol analog tracer, I-131-Norcholesterol (NP-59), localises to adrenal cortical lesions. It has an established role in Conn’s syndrome. It is not expected to concent...

Introduction: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infants and children. Histologically there are two subgroups, diffuse and focal. Fluorine-18-L dihydroxyphenylalanine positron emission tomography (18F-DOPA PET/CT) helps to differentiate focal from diffuse CHI.Objective and hypotheses: To evaluate the feasibility of using 18F-DOPA PET/CT for the diagnosis of focal or diffuse CHI u...

Introduction: Congenital hyperinsulinism (CHI) includes two major histological subtypes; diffuse and focal. Fluorine-18-L dihydroxyphenylalanine positron emission tomography (18F-DOPA PET/CT) has been established as a novel imagining technique to differentiate focal from diffuse CHI. However CT provides only limited soft tissue contrast and exposes the patient to a significant radiation dose. PET/MRI could provide images with an excellent soft tissue contrast, very ...

Background: Surgical resection is the treatment of choice for phaeochromocytomas. Introduction of laparoscopic adrenalectomy (LA) led to a reduction in the number of open adrenalectomies (OA); however, there is limited information comparing the two techniques.Objectives: We report here a comparison of LA and OA operations for phaeochromocytoma performed over 20 years.Methods: We performed a retrospective review of all patients unde...